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CA‐125 levels in ruptured and unruptured tubal ectopic pregnancies
Author(s) -
Malatyalioglu Erdal,
Ozer Sinan,
Kokcu Arif,
Cetinkaya Mehmet B.,
Alper Tayfun,
Tosun Migraci
Publication year - 2006
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2006.00424.x
Subject(s) - medicine , obstetrics , ectopic pregnancy , gynecology , pregnancy , biology , genetics
Aim: This prospective, single‐blind and controlled clinical study aimed to research if CA‐125 levels could be a useful test in the differential diagnosis of intact and ruptured tubal ectopic pregnancy. Methods: Sixty‐five women with tubal ectopic pregnancy of 5–10 weeks’ duration (27 women with ruptured tubal ectopic pregnancy [REP] and 38 women with unruptured tubal ectopic pregnancy [UREP]) and 65 women with normal intrauterine pregnancy (NIUP) of the same gestational age were studied prospectively. Serum CA‐125 levels were measured in all women and these levels were compared among the REP, UREP, and NIUP groups. Results: The mean CA‐125 levels didn’t show any significant difference between the REP and NIUP groups ( P > 0.05). The mean CA‐125 levels of these two groups were higher than that in the UREP group ( P < 0.01, P < 0.001, respectively). The dispersion ratios of the CA‐125 levels had a statistically significant difference between the REP and UREP groups (χ 2 : 42.44, P < 0.0001). CA‐125 levels weren’t correlated with gestational weeks in the REP and UREP groups (r: 0.005, P > 0.05; r: 0.008, P > 0.05, respectively). Conclusion: In intact tubal ectopic pregnancies, expectant or managed with medical treatment, the increase of CA‐125 levels in the serial measurements could be a supplementary test for an early diagnosis of tubal rupture.