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Ovarian carcinomas with neuroendocrine differentiation: Review of five cases referring to immunohistochemical characterization
Author(s) -
Yasuda Masanori,
Kajiwara Hiroshi,
Osamura Yoshiyuki R.,
Hirasawa Takeshi,
Muramatsu Toshinari,
Murakami Masaru,
Takagi Masayuki,
Tadokoro Mamoru,
Kobayashi Youichi,
Inayama Yoshiaki,
Miyagi Etsuko,
Nakatani Yukio
Publication year - 2006
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2006.00419.x
Subject(s) - immunoperoxidase , immunohistochemistry , pathology , neuroendocrine differentiation , medicine , antibody , cancer , monoclonal antibody , immunology , prostate cancer
Aim: To review five ovarian carcinomas with varying degrees of neuroendocrine differentiation (ND) using an immunohistochemical study focused on the relationship with morphological features. Methods: ND was immunohistochemically analyzed using 21 antibodies by an indirect immunoperoxidase method, and ploidy pattern was analyzed using paraffin sections. Results: The tumors were divided according to tumor cell size into ‘small‐sized’ for case 1, ‘intermediate‐sized’ for cases 2 and 3, and ‘large‐sized’ for cases 4 and 5. Expressions of neuroendocrine markers and argyrophil reaction tended to be strengthened as tumor cell size increased. Cases 1, 2 and 3 showed diploid pattern and cases 4 and 5 showed aneuploid pattern. Conclusion: ND of ovarian carcinomas is closely related to morphological features represented by the cell size. Therefore, ovarian carcinomas with ND should be defined because the disease entity is not successfully integrated irrespective of the highly malignant potential.