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Analysis of ovarian tumors for the presence of human papillomavirus DNA
Author(s) -
Quirk Jeffrey T.,
Kupinski John M.,
DiCioccio Richard A.
Publication year - 2006
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2006.00376.x
Subject(s) - medicine , human papillomavirus , virology , dna , oncology , cancer research , gynecology , genetics , biology
Aim: The role of human papillomavirus (HPV) infection in ovarian tumorigenesis is uncertain. The objective of this study was to screen a collection of ovarian tumors for the presence of high‐risk oncogenic HPV types 16, 18 and 33. Methods: Twenty benign and malignant ovarian tumors were obtained from women undergoing pelvic surgery at a regional comprehensive cancer institution in North America. DNA was isolated from the snap‐frozen tumors, and commercial polymerase chain reaction (PCR) detection sets were used to analyze the tumor DNA samples for the presence of DNA from HPV types 16, 18 and 33. Results: The DNA from HPV types 16, 18 and 33 was not detected in any of the ovarian tumors. Conclusions: Our findings do not support an association between infection with HPV types 16, 18 and 33 and ovarian neoplasia in this patient population.