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Ranking the contributing risk factors in venous thrombosis in terms of therapeutic potential: Virchow's triad revisited
Author(s) -
Kiyomura Masaki,
Katayama Tomihiro,
Kusanagi Yasuki,
Ito Masaharu
Publication year - 2006
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2006.00374.x
Subject(s) - medicine , hemoconcentration , microcirculation , platelet , pathology , thrombosis , venous thrombosis , endothelium , venous stasis , immunology , hematocrit
Aim: Thromboemoblism is an attendant feature of a variety of pathological conditions. We reconsidered Virchow's pathogenetic triad of stasis, humoral factors and vascular wall pathologies in the light of platelet behavior in vivo . Methods: Rat mesenteric microcirculation was examined by intravital microscopy. After isolated rat platelets had been injected i.v. into rats, their behavior in venules was examined under the following conditions: stasis from pressure, hemoconcentration from erythropoietin injections, or endothelial damage from tumor necrosis factor‐α. Results: In the endothelial damage group, platelets displayed transient adhesion and rolling, while some platelets exhibited stationary adhesion to venular endothelium. The stasis and hemoconcentration groups exhibited only a slight change in adhesive response. Conclusion: Endothelial dysfunction appears to be the most important contributing factor in the development of venous thrombosis. As such, targeting this dysfunction is suggested for therapeutic intervention.