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Clinicopathologic manifestations of early‐onset endometrial cancer in Japanese women with a familial predisposition to cancer
Author(s) -
Yamagami Wataru,
Susumu Nobuyuki,
Banno Kouji,
Hirao Takeshi,
Kataoka Fumio,
Hirasawa Akira,
Suzuki Nao,
Aoki Daisuke,
Nozawa Shiro
Publication year - 2005
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2005.00318.x
Subject(s) - medicine , endometrial cancer , family history , cancer , pathological , carcinoma , body mass index , survival rate , gynecology , obesity , disease , stage (stratigraphy) , oncology , obstetrics , paleontology , biology
Aim: The number of patients under 40 years of age with early‐onset endometrial cancer is on the rise in Japan. Preservation of fertility in younger patients is a critical issue. In order to examine the clinical and pathological characteristics of these patients, cases of early‐onset endometrial cancer at a single hospital were analyzed. Methods: Seventy‐four patients were diagnosed with endometrial cancer before age 40 and included in this study after obtaining informed consent. Results: The clinical characteristics included a significantly higher prevalence of complications such as nulligravidity and nulliparity ( P < 0.001). Pathologically, well‐differentiated endometrial carcinoma was significantly more frequent ( P = 0.011). The 5‐year survival rate was high (98.7%). In regards to the relationship between clinicopathological features and grade of differentiation, the prevalence of G2 and G3 carcinoma was not significantly lower ( P = 0.24) in patients with obesity. Although the frequency of G2 and G3 carcinoma was significantly higher in patients with a family history of cancer ( P = 0.02), their 5‐year survival rate was not significantly lower (100%). Conclusion: This study found that these two types of early‐onset endometrial cancer are clinicopathologically different. In patients with a family history of cancer, their body mass index was lower, and the frequency of G2 and G3 carcinoma was significantly higher, but their 5‐year disease‐free survival rate was not significantly lower.