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Survival analysis in advanced epithelial ovarian carcinoma in relation to proliferative index of MIB‐1 immunostaining
Author(s) -
Kritpracha Krittaya,
Hanprasertpong Jitti,
Chandeying Verapol,
Dechsukhum Chawaboon,
Geater Alan
Publication year - 2005
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2005.00270.x
Subject(s) - medicine , immunostaining , quartile , hazard ratio , serous carcinoma , confidence interval , serous fluid , ovarian carcinoma , staining , immunohistochemistry , carcinoma , pathology , oncology , cancer , ovarian cancer
Aim: To evaluate the survival of patients with advanced epithelial ovarian carcinoma in relation to MIB‐1 immunostaining, to determine the association between MIB‐1 and clinicopathologic variables, and to identify an appropriate cut‐off point for MIB‐1 immunostaining as a prognostic marker. Methods: We retrospectively reviewed the medical records of women diagnosed with advanced epithelial ovarian carcinoma during 1987–1998. The paraffin‐embedded tissue of recruited women was stained with MIB‐1 immunostaining for review. Results: The records of 105 patients were included. The percentage staining of MIB‐1 ranged from 0.3 to 100%, with a median of 11.9%. MIB‐1 staining was generally higher in serous tumors than in other types ( P = 0.048), but was not associated with other potential prognostic indicators. The 5‐year survival rate among advanced epithelial ovarian carcinoma patients was 25.7%, while that in the high MIB‐1 (greater than or equal to median) and low MIB‐1 (less than median) patients was 15.1% (95% confidence interval [CI] = 7.1–26.0) and 36.5% (95% CI = 23.8–49.4), respectively. Median survival times in the two groups were 1.8 years and 3.0 years, respectively ( P < 0.008). Division of the MIB‐1 staining percentage into quartiles showed that the risk of death increased from the first to the second quartile (≥7.6 to <11.9%, hazard ratio = 2.36, 95% CI = 1.22–4.54) with no further increase in higher quartiles. Conclusion: Among patients with advanced epithelial ovarian carcinoma, MIB‐1 immunostaining was higher in serous than in other histologic types. Levels of MIB‐1 staining above the cut‐off point of 7.6% had significantly poorer survival.