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Use of heparin to lower the incidence of phlebitis induced by anti‐neoplastic agents used in ovarian cancer
Author(s) -
Ikeda Shunichi,
Douchi Tsutomu,
Nagata Yukihiro
Publication year - 2004
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2004.00225.x
Subject(s) - medicine , heparin , partial thromboplastin time , ovarian cancer , chemotherapy , complication , prothrombin time , metastasis , cancer , surgery , neoplastic disease , anesthesia , platelet
Aim: To investigate whether heparin infusion with the administration of anti‐neoplastic agents in ovarian cancer can reduce the occurrence of phlebitis as a complication of chemotherapy. Methods: The subjects were 20 patients with ovarian cancer who developed phlebitis following their first course of anti‐cancer chemotherapy. In the subsequent chemotherapy course, 10 patients received heparin infusion of 5000 U, starting 3 h before the administration of anti‐neoplastic agents and continuing concomitantly with the agents for 12 h. The other 10 patients (control) were treated with anti‐neoplastic agents alone. Results: Only one (10%) of 10 patients who had received heparin developed phlebitis, while eight patients (80%) in the control group did ( P = 0.005). In the heparin group, there were no toxic effects of heparin observed. The prothrombin time, activated partial thromboplastin time, fibrinogen, and platelet count did not differ before and after the completion of chemotherapy. Conclusion: Concurrent infusion of heparin and anti‐neoplastic agents in ovarian cancer is a safe and effective method of preventing phlebitis induced by chemotherapy.