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Therapeutic termination of second trimester pregnancies with intrauterine fetal death with 400 micrograms of oral misoprostol
Author(s) -
Pongsatha Saipin,
Tongsong Theera
Publication year - 2004
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2004.00184.x
Subject(s) - misoprostol , medicine , obstetrics , fetus , pregnancy , cervix , fetal death , abortion , gestation , regimen , intrauterine death , prospective cohort study , gynecology , surgery , genetics , cancer , biology
Abstract Objective: To assess the efficacy and maternal side‐effects of oral misoprostol for second trimester termination of pregnancies with intrauterine fetal death. Methods: A prospective descriptive study was conducted on 63 pregnant women who had intrauterine fetal death with unfavorable cervix (Bishop scores ≤4). All received 400 µg of misoprostol orally every 4 h until favorable cervix was achieved. Main outcome measures included success rate of termination within 12, 24, 36 and 48 h, mean induction to delivery time and maternal side‐effects. Results: The success rates of termination within 12, 24, 36, 48 h were 50.8%, 84.1%, 88.9% and 92.1%, respectively. Mean induction to delivery time in cases of delivery within 48 h was 13.2 ± 8.4 h, range 2.25–22.9 h. The most common maternal side‐effect was chill (33.3%). No serious maternal complication was detected. Conclusion: 400 µg oral misoprostol every 4 h is effective for pregnancy termination in cases of intrauterine fetal death and may be an alternative regimen because of its ease and convenience.