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Ultrasound‐guided local injection of methotrexate to treat an invasive hydatidiform mole
Author(s) -
Tsukihara Satoru,
Harada Tasuku,
Terakawa Naoki
Publication year - 2004
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2004.00179.x
Subject(s) - medicine , methotrexate , ultrasound , ultrasonography , systemic therapy , mole , surgery , radiology , cancer , breast cancer
A 28‐year‐old Japanese woman had an invasive hydatidiform mole which was diagnosed by means of transvaginal ultrasonography. After the two initial courses of systemic methotrexate (MTX) therapy given over a period of weeks, the tumor was 14 mm in diameter and the surrounding blood supply remained rich. In addition to the two initial courses of systemic MTX therapy, local ultrasound‐guided injection of MTX therapy was given three times, once per week. After the local MTX treatment, the βhCG level, which had been as high as 240 ng/mL, dropped to less than 0.1 ng/mL. We then gave two additional courses of systemic MTX therapy (once per week). More than 3 years have passed since the final systemic MTX therapy, and the patient's serum βhCG levels continue to be less than 0.1 ng/mL. An invasive mole can be treated with an ultrasound‐guided local injection of MTX in addition to the established systemic MTX treatment.