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Management of Pregnancy with Congenital Antithrombin III Deficiency: Two Case Reports and a Review of the Literature
Author(s) -
Yamada Takahiro,
Yamada Hideto,
Morikawa Mamoru,
Kato Emi H.,
Kishida Tatsuro,
Ohnaka Yoshito,
Nikaido Hiroki,
Ozawa Tetsuo,
Fujimoto Seiichiro
Publication year - 2001
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2001.tb01250.x
Subject(s) - medicine , pregnancy , antithrombin , aspirin , heparin , thrombosis , adverse effect , surgery , pediatrics , obstetrics , genetics , biology
Women with antithrombin (AT) III deficiency are prone to pregnancy‐associated venous thromboembolism. We report 2 cases with genetically confirmed ATIII deficiency, one with a mutation in exon 3A and the other with an exon 4 deletion, in whom the pregnancies were successfully managed with prophylactic therapies for thrombosis. A 35‐year‐old pregnant woman was treated with intravenous infusions of ATIII concentrate alone, and the other 22‐year‐old pregnant woman was mainly treated with subcutaneous injections of heparin and oral low‐dose aspirin therapy. Both pregnancies resulted in vaginal deliveries of healthy neonates. The literature concerning prophylactic therapies for thrombosis in ATIII deficiency‐complicated pregnancy is reviewed, and the clinical problems, including the adverse effects of the therapies, are discussed.