Premium
Bacterial Vaginosis in Early Pregnancy and Adverse Pregnancy Outcome
Author(s) -
Purwar Manorama,
Ughade Suresh,
Bhagat Bharti,
Agarwal Vandana,
Kulkarni Hemant
Publication year - 2001
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2001.tb01248.x
Subject(s) - bacterial vaginosis , medicine , pregnancy , prom , obstetrics , premature rupture of membranes , incidence (geometry) , cohort study , prospective cohort study , odds ratio , gynecology , gestation , genetics , physics , optics , biology
Objective: to assess the prevalence of bacterial vaginosis (BV) in asymptomatic pregnant women and its association with preterm birth (PTB) and premature rupture of membranes (PROM). Methods: In a cohort study 1,006 pregnant women between 16–28 weeks' gestation were screened for BV (Nugent's criteria) and for lower genital tract infection. Women were followed to confirm pregnancy outcome. Data were analyzed using STATA software. Univeriate and multivariate methods were used to investigate the association between bacterial vaginosis and adverse pregnancy outcome. Results: Prevalence of BV was 11.53%. Baseline characteristics were similar for both groups, 6.8% women were lost to follow‐up. Incidence of PTB was higher in BV positive women compared to BV negative women (p = 0.001). On multiple logistic regression (MLR), BV was associated with an increasd risk of PTB (p = 0.001) and PROM (p = 0.001), other correlates being previous PTB (p = 0.003) and the presence of enteropharynangeal organisms in vagina (p = 0.03). BV accounted for 82.53% of the attributable risk for PTB. Conclusion: Presence of BV in early pregnancy is associated with an increased risk of PTB and PROM. Multicentric interventional study is recommended.