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Body Fat Distribution as a Risk Factor of Endometrial Cancer
Author(s) -
Iemura Akiko,
Douchi Tsutomu,
Yamamoto Shinako,
Yoshimitsu Nobuyuki,
Nagata Yukihiro
Publication year - 2000
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2000.tb01352.x
Subject(s) - endometrial cancer , medicine , trunk , body mass index , body adiposity index , menopause , classification of obesity , risk factor , body fat distribution , obesity , endocrinology , cancer , gynecology , physiology , fat mass , biology , ecology
Objective: To investigate the relative contributions of upper body fat distribution and overall adiposity to endometrial cancer risk. Methods: Subjects were 63 postmenopausal women with endometrial cancer aged less than 70 years and 201 age‐matched controls. Age, age at menopause, years since menopause, height, weight, and body mass index were recorded at the time of admission. The trunk‐leg fat ratio, body fat mass, trunk fat mass, and the percentage of body fat were measured by dual‐energy X‐ray absorptiometry. Results: Trunk‐leg fat ratio was higher in endometrial cancer patients than in controls (1.40 + 0.59 vs 1.23 + 0.39, p < 0.05). Whereas, other variables including age at menopause, percentage of body fat, body fat mass, and body mass index did not differ between the 2 groups. On stepwise multiple regression analysis, the trunk‐leg fat ratio was still correlated with the presence of endometrial cancer (p < 0.05). Conclusions: Upper body fat distribution rather than overall adiposity is associated with endometrial cancer risk.