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Antioxidant Nutrients and Lipid Peroxide Levels in Thai Preeclamptic Pregnant Women
Author(s) -
Panburana Panyu,
Phuapradit Winit,
Puchaiwatana Orawan
Publication year - 2000
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.2000.tb01343.x
Subject(s) - preeclampsia , lipid peroxide , medicine , antioxidant , vitamin e , malondialdehyde , vitamin c , nutrient , pregnancy , endocrinology , vitamin , lipid peroxidation , oxidative stress , biochemistry , chemistry , biology , organic chemistry , genetics
Objective: To compare the antioxidant nutrients and lipid peroxide levels in preeclampsia and normal pregnant women. Methods: Antioxidant nutrients (vitamin A and E) were measured by high‐pressure liquid chromatography, vitamin C was measured by the dinitrophenyl hydrazine method, lipid peroxides were measured by the malondialdehyde method in 20 severe preeclampsia, 30 mild preeclampsia and 60 normal pregnant women as controls. Results: Vitamin C levels in severe and mild preeclampsia were significantly less than those in control group. The corrected vitamin E and vitamin A levels were significantly decreased only in severe preeclampsia. While the lipid peroxide levels in both mild and severe preeclampsia were significantly increased when compared with the nomal pregnancy. Conclusions: Preeclampsia is associated with the imbalance between lipid peroxides and antioxidant nutrients (vitamin C and E). The imbalances favour lipid peroxides with the increasing severity of preeclampsia.