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Menstrual Disorders in Patients Undergoing Chronic Hemodialysis
Author(s) -
Kawashima Rieko,
Douchi Tsutomu,
Oki Toshimichi,
Yoshinaga Mitsuhiro,
Nagata Yukihiro
Publication year - 1998
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.1998.tb00110.x
Subject(s) - medicine , amenorrhea , prolactin , hemodialysis , etiology , menstrual cycle , hormone , physiology , pregnancy , genetics , biology
Objective: To investigate the etiology of menstrual disorders in patients undergoing chronic hemodialysis (CHD). Methods: The menstrual histories, along with hormonal, biochemical, and hematological data, were investigated in 25 reproductive‐aged CHD patients. Results: All subjects had had regular menstrual cycles before entering CHD therapy. Of the 20 women who developed amenorrhea after beginning CHD therapy, 8 showed a return to their regular cycles and 6 improved to oligomenorrhea, 3 months to 66 months later, while 6 remained amenorrheic. The serum prolactin (PRL) levels were significantly higher in the patients ( n = 9) with normogonado‐tropic amenorrhea or oligomenorrhea than in patients ( n = 13) with regular cycles (53.6 ± 36.2 vs 27.8 + 15.2 ng/m l , p < 0.05). The serum LH levels were high in both groups. In a cross‐sectional study, the serum PRL levels gradually decreased with longer duration of dialysis. Conclusions : Patients undergoing CHD are likely to develop menstrual disorders. Hyperprolactinemia in part contributes to these menstrual disorders. However, menstrual disorders in CHD patients tend to improve during long‐term follow‐up, because of the gradual decrease in serum PRL levels during long‐term CHD therapy.