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Intrahepatic Vein Fetal Blood Sampling: Current Role in Prenatal Diagnosis
Author(s) -
Chinnaiya Anandakumar,
Venkat Annapoorna,
Dawn Chia,
Chee Wong Yee,
Choo Koh Bee,
Gole Leena Abhijit,
Meng Chua Tsei
Publication year - 1998
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.1998.tb00083.x
Subject(s) - medicine , fetus , umbilical cord , umbilical vein , obstetrics , gestational age , blood sampling , vein , cord blood , pregnancy , gynecology , surgery , biochemistry , chemistry , genetics , biology , in vitro , anatomy
Objective : To identify the site of fetal blood sampling (FBS) with lesser complications; and also analyses the reasons for targetting the intrahepatic vein (IHV) for FBS. Methods : Fetal blood sampling (FBS) performed on 382 women over a period of 7 years at the National University Hospital, Singapore was analysed. FBS was performed from 13 weeks of gestational age onwards. In 76.4% (292 of 382) the intrahepatic part of the umbilical vein (IHV) was targetted; in 18.3% (70 of 382) percutaneous umbilical cord sampling (PUBS) was performed; in 5.2% (20 of 382) cardiocentesis was performed to obtain fetal blood. Results : Multivariate analysis showed an increase in odds of fetal loss for umbilical cord and cardiocentesis groups compared with the IHV FBS group. It was statistically significant (p < 0.01) only in the cardiocentesis group for fetal loss at < 2 weeks of performing the procedure.