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The First 2 Case Reports of Frozen Embryo Donation Twin Pregnancies in Singapore: Hormonal Profiles and Obstetrical Outcome
Author(s) -
Chan Clement L. K.,
Kumar Jothi,
Yong Eu L.,
Fong Chui Y.,
Bongso Ariff,
Ng Soon C.
Publication year - 1998
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.1998.tb00076.x
Subject(s) - medicine , embryo donation , obstetrics , twin pregnancy , gynecology , donation , outcome (game theory) , pregnancy , fetus , biology , genetics , mathematics , mathematical economics , economics , economic growth
A 35‐year‐old woman with premature ovarian failure and another 30‐year‐old woman with gonadal dysgenesis were the recepients of donated supernumerous frozen embryos after successfully prepared with cyclic steroid replacement therapy as described previously. 1,2 ) One patient received 4 and the second 2 frozen embryos, transferred transcer‐vically on the 3rd day of progesterone administration. Both patients had viable twin pregnancies. The plasma βhCG levels for both patients at 2 weeks post replacement (4 weeks gestation) were lower than the median values in our normal, uncomplicated singleton pregnancy for the same gestation. The levels after 4 weeks post‐replacement (6 weeks gestation) became comparable. Plasma progesterone profiles suggested a level of above 70 ng/m l would be enough to support the twin pregnancies. The first patient developed antepartum haemorrhage of unknown origin at 34 weeks of gestation preceding preterm premature rupture of membranes and subsequently had preterm labour. The second patient developed proteinuric hypertension at 33 weeks of gestation. Both ended in a lower segment cesarean section. Both sets of twins and their mothers were discharged well.