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Immunohistochemical and Molecular Studies on Malignant Transformation in Mature Cystic Teratoma of the Ovary
Author(s) -
Yoshioka Tomomi,
Tanaka Toshinobu
Publication year - 1998
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.1998.tb00057.x
Subject(s) - dermoid cyst , malignant transformation , pathology , immunohistochemistry , medicine , mature cystic teratoma , ovary , cyst , teratoma , basal cell , carcinoma , cell , pathogenesis , biology , genetics
Objectives: To determine a useful tumor marker for detecting squamous cell carcinoma arising in a dermoid cyst, and to find the molecular pathogenesis of this condition. Methods: In 4 cases of squamous cell carcinoma arising in a dermoid cyst and 22 cases of dermoid cyst, we studied tissue expressions and serum levels of squamous cell carcinoma antigen (SCC), CA 19‐9 and CA 125, and the mutation of the p 53 tumor suppressor gene. Results: Three of 4 malignant cases had either positive SCC expressions or elevated serum SCC levels. The mean serum SCC level in benign cases was below the cut‐off level. CA 19‐9 and CA 125 were not detected in squamous cell carcinoma. p 53 overexpressions were observed in all malignancies. Conclusion: These results suggested that the serum SCC might be a useful marker for detecting squamous cell carcinoma arising in a dermoid cyst, and that the mutation of p 53 might be one of the genetic events in the malignant transformation of a dermoid cyst.