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Elevated Fetal Fibronectin in Midtrimester Amniotic Fluid Is Involved with the Onset of Preeclampsia
Author(s) -
Sakura Mari,
Nakabayashi Masao,
Takeda Yoshihiko,
Sato Kodo
Publication year - 1998
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.1998.tb00055.x
Subject(s) - medicine , amniotic fluid , preeclampsia , fetal fibronectin , obstetrics , fetus , pathogenesis , gestation , pregnancy , fibronectin , prospective cohort study , andrology , preterm labor , extracellular matrix , genetics , biology , microbiology and biotechnology
Objective: To examine early midtrimester amniotic fluid for its significance in pregnancy outcomes, especially with connection to the pathogenesis of preeclampsia. Methods: A prospective, nested, case‐control study was conducted. Fetal fibronectin in early midtrimester (16—20 weeks gestation) amniotic fluid was measured by EIA method. Results were compared by their pregnancy outcomes. Results: Amniotic fluid levels of fetal fibronectin were significantly higher in the group subsequently developing severe preeclampsia (106.8 ± 13.2 μg/m/, mean± SD, n = 12) compared with matched controls (66.7 ± 7.1 μg/m l , n = 12) (p < 0.05). Conclusion : High levels of fetal fibronectin were found in the amniotic fluid of women subsequently developing severe preecalmpsia before any symptom appear. Involvement of extracellular injury or cellular hyperactivity in the midtrimester pla‐cental site with the onset of preeclampsia is suggested.