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Pregnancy in a Patient of Glanzmann's Thrombasthenia with Antiplatelet Antibodies
Author(s) -
Kashyap Rajesh,
Kriplani Alka,
Saxena Renu,
Takkar D.,
Choudhry V. P.
Publication year - 1997
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.1997.tb00839.x
Subject(s) - medicine , thrombasthenia , glanzmann's thrombasthenia , platelet , pregnancy , platelet transfusion , platelet membrane glycoprotein , prednisolone , gastroenterology , pediatrics , surgery , platelet aggregation , biology , genetics
Glanzmann's thrombasthenia is an autosomal recessive, inherited platelet function disorder. There is an absence of glycoprotein (GP) IIb/IIIa on the platelet membrane which causes reduced platelet aggregation with a defective platelet haemostatic plug formation. The management of bleeding episodes in these patients with platelet transfusions may result in alloimmunization and make the successive transfusions less effective. Pregnancy and delivery is rare in these patients and is associated with a high risk of severe haemorrhage. We describe a primigravida with Glanzmann's thrombasthenia and alloimmunization who developed secondary postpartum haemorrhage and was successfully treated with oral prednisolone.