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Risk Factors Predictive of Para‐Aortic Lymph Node Metastasis in Endometrial Carcinomas *
Author(s) -
Yokoyama Yoshihito,
Maruyama Hidetoshi,
Sato Shigemi,
Saito Yoshiharu
Publication year - 1997
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.1997.tb00829.x
Subject(s) - medicine , univariate analysis , metastasis , lymphadenectomy , multivariate analysis , hysterectomy , oncology , endometrial cancer , radical hysterectomy , stage (stratigraphy) , pathological , lymph node , pathology , cervical cancer , cancer , paleontology , biology
Abstract Objective : To identify risk factors predictive of para‐aortic lymph node (PAN); metastasis in endometrial carcinomas. Methods : Sixty patients with endometrial carcinomas Stage I to III (FIGO, 1988) who each underwent a complete pelvic and para‐aortic lymphadenectomy with a semiradical or radical hysterectomy, bilateral salpingo‐oophorectomy, between April 1988 and March 1996, were included in this study. The relationship between PAN metastasis and clinico‐pathological factors such as histological type, grade, depth of myometrial invasion (MI), vascular space involvement (VSI), cervical invasion (CI), peritoneal cytology, tumor size, pelvic lymph node (PLN) metastasis, and glutathione S‐transferase π (GST‐π) expression was examined using univariate and multivariate analysis. Results : Seven variables — G3 grade, more than one‐half MI, positive VSI, positive CI, tumor size of more than 2 cm in diameter, positive PLN metastasis, and positive GST‐π — were significantly correlated with PAN metastasis using univariate analysis. Multivariate analysis revealed that of the above 7 variables, 3 were significantly and independently correlated with PAN metastasis: more than one‐half MI, positive PLN, and positive GST‐π. The relative risk of a patient with these 3 factors having PAN metastasis was 18.0 times greater than the risk for a patient without them. Conclusion : These variables — More than one‐half MI, positive PLN, and positive GST‐π — were significantly related to PAN metastasis.