Premium
Pregnancy Rates Using CC/hMG or hMG Alone
Author(s) -
Ziadeh Saed M.,
Zakaria Muhannad R.,
AbuHieja Adel
Publication year - 1997
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.1997.tb00813.x
Subject(s) - medicine , pregnancy , hmg coa reductase , group b , pregnancy rate , gynecology , group a , infertility , incidence (geometry) , menotropins , obstetrics , ovulation induction , ovulation , controlled ovarian hyperstimulation , ovarian hyperstimulation syndrome , in vitro fertilisation , hormone , biochemistry , chemistry , genetics , physics , optics , reductase , biology , enzyme
Objective : The purpose of our study was to determine which of the two drug regimens is more successful in achieving conception in the infertile couple. Subjects : One hundred and sixty women with primary infertility were included in this study. Group A, consisted of 102 patients were treated with clomiphene citrate (CC) and human menopausal gonadotrophin (hMG). Group B, consisted of 58 patients were treated with hMG alone. Methods : This retrospective study was performed between April 1993 and March 1996, to compare the pregnancy rates in women using two drug regimens with ultrasound scan and serum E 2 to monitor ovulation induction. Results : The pregnancy rate per patient in Group A was significantly higher than in Group B (46% vs 25.9%) as was the pregnancy rate per treatment cycle (31.3% vs 15.8%) pregnancy loss was lower in Group A than in Group B (17% vs 33.3%). The incidence of multiple pregnancy was 8.5% in Group A, and 13.3% in Group B. While the incidence of ovarian hyperstimulation syndrome was 3% in Group A, and 6.9% in Group B. Conclusions : We concluded that the use of CC + hMG in an assisted conception programme gives a better pregnancy rate 46% than in the hMG alone 25.9%. These data with the use of U/S scan and serum E 2 clearly showed that the use of CC + hMG is a successful and safe method for the treatment of infertile patients.