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Immunotherapy with Husband's Leukocytes to Primary Habitual Aborters and Autoantibodies in Their Sera
Author(s) -
Takesako Shunji,
Fujino Toshinori,
Shiokawa Hironobu,
Iwamoto Ichiro,
Ikeda Toshiro,
Nagata Yukihiro
Publication year - 1997
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.1997.tb00805.x
Subject(s) - medicine , autoantibody , immunology , immunotherapy , primary (astronomy) , antibody , immune system , physics , astronomy
Objective : This study was performed to determine whether primary habitual aborters have an autoimmunological tendency and whether immunotherapy with leukocytes induces autoantibodies in their sera. Methods : We measured the levels of antiphospholipid antibodies (APAs) and antinuclear antibodies (ANAs) in the sera of 65 primary habitual aborters. Among them, 8 primary habitual aborters received immunotherapy with their respective husband's leukocytes; these 8 patients were followed up for autoantibodies in their sera before immunotherapy, at the time of pregnancy permission, during the first trimester of pregnancy, at delivery, and postpartum. Results : Sixty‐nine percent of the 65 primary habitual aborters were positive for IgG or IgM antibodies to at least 1 of 6 phospholipids, and 29% of them were positive for ANAs. Although the pregnancy outcomes of the 8 primary habitural aborters after immunotherapy were good, their APAs and ANAs converted to positive after the immunotherapy. Conclusion : Immunotherapy with leukocytes should be performed after checking and confirming the absence of autoantibodies in the sera of a habitual aborter.