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Hybrid Capture™ Method for Detection of Human Papillomavirus DNA in Clinical Specimens: A Tool for Clinical Management of Equivocal Pap Smears and for Population Screening
Author(s) -
Lörincz Attila T.
Publication year - 1996
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.1996.tb01081.x
Subject(s) - hybrid capture , medicine , human papillomavirus , cervical cancer , dna testing , population , pap test , oncology , cervical cancer screening , gynecology , cancer , obstetrics , cervical intraepithelial neoplasia , genetics , environmental health , biology
and Key Words High‐ and intermediate‐risk types of human papillomavirus (HPV) in concert with cofactors are responsible for over 90% of cervical cancers world‐wide. While the Pap smear is a valuable cancer prevention tool, its subjective nature leaves it error prone. As a result, HPV DNA testing appears to be a needed adjunct to the Pap smear. Hybrid Capture is a simple DNA test with high specificity and sensitivity which appears useful for clinical management of equivocal Pap tests and shows promise for mass screening.