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Sertoli Leydig Cell Tumor with Malignant Heterologous Elements and Raised Alpha‐Fetoprotein: A Case Report
Author(s) -
Singh Zeba N.,
Singh Manoj K.,
Chopra Prem
Publication year - 1996
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.1996.tb01076.x
Subject(s) - leydig cell , heterologous , medicine , sertoli cell , alpha fetoprotein , leydig cell tumor , alpha (finance) , endocrine system , pathology , cancer research , hormone , oncology , biology , surgery , biochemistry , construct validity , spermatogenesis , patient satisfaction , hepatocellular carcinoma , gene , luteinizing hormone
A case of a Sertoli Leydig cell tumor in a young female with virilizing symptoms and an androgenic endocrine profile with raised serum alpha‐fetoprotein is presented. The tumor consisted predominantly of malignant epithelial and mesenchymal heterologous elements. Such a combination in the same tumor has to the best of our knowledge not been previously reported in English literature. The Leydig cells were immnohistochemically positive for alpha‐fetoprotein. Sertoli Leydig cell tumors should be included in the differential diagnosis of tumors with raised alpha‐fetoprotein. Chemotherapy in addition to surgery has been recommended for these tumors.