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Clinical Utility of Calculated Creatinine Clearance as a Guide to Chemotherapy in Patients with Gynecologic Malignancies *
Author(s) -
Kang SoonBoem,
Kim ByoungGie,
Song YongSang,
Lee HyoPyo
Publication year - 1996
Publication title -
journal of obstetrics and gynaecology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1341-8076
DOI - 10.1111/j.1447-0756.1996.tb00939.x
Subject(s) - medicine , gynecologic cancer , chemotherapy , creatinine , oncology , urology , intensive care medicine , ovarian cancer , cancer
Objective : To examine the relationship between calculated and measured creatinine clearance, and also to evaluate the clinical utility of calculated creatinine clearance before administration of chemotherapy in patients with gynecologic malignancies. Methods : In 38 patients with gynecologic malignancies, a total‐69 paired creatinine clearance measured by 24‐hour urinary creatinine clearance and calculated were compared. Results : The significant correlation (r = 0.597, p < 0.0001) was observed between creatinine clearances determined by both methods. There were 26 (37.7%) 24‐hour urine collections. The correlation between two methods improved when these inaccurate samples were excluded (r = 0.876, p < 0.0001). In addition, if a creatinine clearance of 50 ml/min is set as a threshold for dose modification, only 2.9% of the patients would have received reduced doses inappropriately, by using the calculated creatinine clearance alone. Conclusion : These results suggest that in patients with gynecologic malignancies, a calculated creatinine clearance prior to chemotherapy is sufficient for evaluation of renal function and measured creatinine clearance would be determined only when calculated creatinine clearance is below the threshold for dose modification.