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Second and Early Third Trimester Atrial Natriuretic Peptide (ANP) Levels in Pregnancies Subsequently Complicated by Hypertension
Author(s) -
Chung Tony K. H.,
Rogers Michael S.,
Baldwin Sally,
Chang Allan M. S.,
Nicholls M. Gary
Publication year - 1995
Publication title -
journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1340-9654
DOI - 10.1111/j.1447-0756.1995.tb01046.x
Subject(s) - atrial natriuretic peptide , medicine , cardiology , pregnancy , fetal heart , endocrinology , fetus , biology , genetics
Objective : To explore the clinical utility of measuring atrial natriuretic peptide (ANP) in the second and early third trimesters of pregnancy in order to predict pregnancy induced hypertension (PIH). Methods and Materials : The study was done in a University Teaching Hospital. A prospective study of 200 women in their first pregnancy was conducted. ANP was measured at 2 gestational windows, 20–26 weeks and 30–34 weeks. This was correlated with pregnancy outcomes, in particular PIH. Student's t ‐test was used to compare ANP levels between women who developed PIH and those who did not. The receiver operator curve (ROC) was used to determine its clinical utility. Results : ANP levels were lower at 20–26 weeks in women who subsequently developed PIH but there was no significant difference at 30–34 weeks between women who had normotensive pregnancies and those who later developed PIH. The character of the ROC would indicate that it is not useful for prediction. Conclusion : ANP levels in the second and early third trimesters has limited clinical utility for the prediction of PIH.