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Mid‐Second Trimester Organic Acids in Severe Open Neural Tube Defects
Author(s) -
Legge Michael
Publication year - 1995
Publication title -
journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1340-9654
DOI - 10.1111/j.1447-0756.1995.tb01041.x
Subject(s) - neural tube , medicine , amniotic fluid , phenylalanine , fetus , tyrosine , organic acid , spina bifida , metabolism , gestation , second trimester , neural tube defect , pregnancy , amino acid , chromatography , biochemistry , embryo , surgery , chemistry , biology , genetics , microbiology and biotechnology
Abstract Objective : To investigate amnioic fluid organic concentrations at 16 weeks gestation from normal fetuses and those affected by severe neural tube defects. Methods : Amniotic fluid collected from normal, anencephalic and severe open spina bifida fetuses was analysed for upto 24 organic acids by gas liquid chromatography. Results : Significant increase in organic acids similar to those observed in defects of phenylalanine and tyrosine metabolism were identified when compared with the normal fetuses. Significant differences in organic acid concentrations were also identified within the two neural tube defect groups. Conclusion : A relationship between phenylalanine and tyrosine metabolism, closure rate of the neural tube and folate metabolism is proposed.