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Two Cases of Monozygotic Twins, in Each of Which One Fetus Was Prenatally Diagnosed as Having a Heart Anomaly
Author(s) -
Negishi Hiroaki,
Okuyama Kazuhiko,
Sagawa Tadashi,
Makinoda Satoru,
Fujimoto Seiichiro
Publication year - 1995
Publication title -
journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 1340-9654
DOI - 10.1111/j.1447-0756.1995.tb01013.x
Subject(s) - fetus , medicine , single umbilical artery , fetal echocardiography , cardiology , pulmonary atresia , etiology , heart disease , regurgitation (circulation) , prenatal diagnosis , pregnancy , genetics , biology
In each of the 2 cases of monozygotic twins reported here, 1 of the fetuses was suspected, as a result of a prenatal ultrasonographic examination, of having congenital heart disease (CHD). One of twins (Case 1) had a hypoplastic left heart (HPLH), coarctation of the aorta (CoA), mitral stenosis (MS), and an atrial septal defect (ASD). Of the other twins (Case 2), 1 fetus had pure pulmonary atresia (PPA) and tricuspid regurgitation (TR). In Case 1, the fetus with CHD had a single umbilical artery, the other had otherwise. In Case 2, the fetus with CHD had a velamentous insertion and an accessory placenta, and the other fetus had a marginal insertion. These findings suggest that environmental factors such as blood flow, blood pressure and so on have a role in the etiology of CHD.