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Development of an Effective and Simple Insemination Method for the in vitro Fertilization of Patients with Male‐Factor Infertility
Author(s) -
Inagaki Shiro,
Suganuma Nobuhiko,
Kitagawa Takeshi,
Fukugaki Hiroyuki,
Nakamur Kiyoshi,
Kondo Ikuyo,
Tomoda Yutaka
Publication year - 1994
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1994.tb00484.x
Subject(s) - infertility , in vitro fertilisation , human fertilization , insemination , pregnancy rate , tubal factor infertility , gynecology , medicine , andrology , male infertility , pregnancy , sperm , biology , genetics , anatomy
An insemination method involving mechanical removal of the cumulus and multiple oocytes per dish (MRC‐MOPD) was applied to achieve in vitro fertilization (IVF) of patients with male‐factor infertility, and the prognosis of IVF and embryo transfer was evaluated. Although the fertilization rate of patients with male‐factor infertility was only 41.4% (12/29) using standard insemination methods, a 73.0% (27/ 37) fertilization rate was achieved with the MRC‐MOPD method. Moreover, 10 patients with male‐factor infertility who were treated with the MRC‐MOPD method achieved clinical pregnancy. A comparison of the results in the 10 patients who were treated with both methods in common reveals that the MRC‐MOPD method also increased the fertilization rate per oocyte. The rate of occurrence of polyploid fertilization did not increase, although large numbers of sperm were inseminated via the MRC‐MOPD method. These results indicate that the MRC‐MOPD method is an effective and simple insemination technique to achieve successful IVF of patients with male‐factor infertility.