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Extra Gonadal Germ Cell Tumours: Report of Two Cases
Author(s) -
Kumar Lalit,
Kumar Sunesh,
Kamble R.M.,
Sharma Suash
Publication year - 1994
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1994.tb00466.x
Subject(s) - asymptomatic , mediastinum , cisplatin , germ cell tumors , embryonal carcinoma , medicine , germ cell , chemotherapy , pathology , oncology , radiology , biology , biochemistry , cellular differentiation , gene
Extra gonadal germ cell tumours (EGGCT) in women are rare. We report here two such patients. The clinical and laboratory features were — young age, 25 and 22 years, midline location (mediastinum, scalp), elevated tumour marker and normal ovaries on CAT scan. The histological subtype was embryonal carcinoma in both cases. Complete response (CR) was achieved with cisplatin based chemotherapy (CT). Both patients had return of normal ovarian functions and have delivered normal babies (1st patient one, 2nd patient 2 babies). Both remain asymptomatic and disease‐free at 30 + and 55 + months follow‐up. We conclude that patients with EGGCT after treatment with cisplatin based CT achieve CR with return of normal ovarian functions and prolonged survival.