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Prostaglandins Biosynthesis in the Rabbit Uterine Cervix at Various Stages of Pregnancy
Author(s) -
Okawa Toshiaki,
Suzuki Yosuke,
Hoshi Kazuhiko,
Endo Chikara,
Sato Akira,
Nakanishi Hironori
Publication year - 1993
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1993.tb00404.x
Subject(s) - pregnancy , alpha (finance) , biosynthesis , cervix , ripening , prostaglandin , endocrinology , early pregnancy factor , medicine , ionophore , prostaglandins f , cervical dilation , chemistry , andrology , biology , gestation , biochemistry , calcium , surgery , botany , enzyme , genetics , cancer , patient satisfaction , construct validity
The accumulation of prostaglandins (PGs: 6‐keto PGF 1α , PGE 2 , PGF 2α , and TXB 2 ) elicited by A‐23187, a Ca 2+ ‐ionophore, was studied in the uterine cervical tissue taken from non‐pregnant and pregnant (10th, 20th and 30th day of pregnancy) rabbits in vitro . At every stage of pregnancy, the accumulation of PGs levels increased as follows; 6‐keto PGF 1α , PGE 2 , PGF 2α and TXB 2 . Biosynthesis of each began to increase from the 20th day of pregnancy, and was significantly elevated at the 30th day. Especially, 6‐keto PGF 1α and PGE 2 were remarkably higher than PGF 2α and TXB 2 at term, and so they are thought to play a more important role in cervical dilation and ripening than the other PGs. Six‐keto PGF 1α was significantly elevated on the 20th day, when other PGs had not yet began to increase. It is thus conceivable that PGI 2 plays an important role in the predispositing of cervical ripening.