Premium
Serum Manganese Superoxide Dismutase (MnSOD) and Histological Virulence of Ovarian Cancer
Author(s) -
Nishida Takashi,
Sugiyama Toru,
Kataoka Akio,
Tashiro Masamichi,
Yakushiji Michiaki,
Ishikawa Mutsuo
Publication year - 1993
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1993.tb00403.x
Subject(s) - superoxide dismutase , serous fluid , histology , ovarian cancer , stage (stratigraphy) , medicine , cancer , gastroenterology , biology , oxidative stress , paleontology
The serum level of a scavenging enzyme, manganese superoxide dismutase (MnSOD), was examined in 78 patients with ovarian cancer. Tumors included 27 stage I, 6 stage II, 37 stage III and 8 stage IV diseases. They were classified as 43 serous, 18 mucinous, 10 clear cell and 7 endometrioid neoplasms, and grouped into 25 grade I, 27 grade II and 26 grade III cancers. Factors affecting the MnSOD level were estimated by analysis of variance and Bonferroni t ‐test. From these, both the stage and histology were less‐effectively affected by the level, while the histological grade was estimated as effective with p<0.05. The MnSOD value increased significantly in accordance with the escalation of the tumor grade with p=0.02 for grade I vs II, 0.005 for II vs III, and 0.0001 for I vs III respectively. MnSOD determination may be unique as a predictor of the histological virulence of ovarian carcinoma.