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Heterophile Antigens in Serous Cystadenocarcinoma of the Human Ovary
Author(s) -
Kamada Masaharu,
Mori Tsuneatsu,
Sakamoto Yasuki,
Daitoh Toshifumi,
Furumoto Hiroyuki,
Irahara Minoru,
Aono Toshihiro,
Mori Takahide
Publication year - 1992
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1992.tb00335.x
Subject(s) - heterophile , ovary , serous fluid , antigen , medicine , biology , pathology , immunology
As the aberrance of carbohydrate moieties, the appearance of heterophile antigens in human ovarian cancer tissue was studied using various heterophile antigens and antibodies together with antisera raised in rabbits by immunization with extracts of human ovarian cancer tissues. In the immunodiffusion test, rabbit antisera reacted with a heat‐stable, perchloric‐acid extractable antigen that was different from CEA and CA125 and possessed Hanganutziu‐Deicher (HD)‐type specificity in all 4 specimens of serous cystadenocarcinoma of the ovary. Furthermore, a pathologic serum with strong HD‐antibody complex formed a precipitin line with one of them. In the cancer tissue, we also immunochemically demonstrated the presence of rat‐erythrocyte antigens. However, other types of heterophile antigens, such as Paul‐Bunnell and Forssman, were not detected. These results suggest that HD‐type antigens appear in serous cystadenocarcinoma of the human ovary, one in broad distribution and some in specific cases.