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Thymidylate Synthase Activity in Normal and Malignant Gynecologic Tissues
Author(s) -
Suzuki M.,
Ohwada M.,
Tamada T.
Publication year - 1992
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1992.tb00334.x
Subject(s) - thymidylate synthase , cervical cancer , cervix , endometrial cancer , cancer , pathology , medicine , biology , endocrinology , fluorouracil
We assayed thymidylate synthase (TS) activity in normal and malignant gynecologic tissues. TS activity in the normal cervix, secretory endometrium, and ovaries from a total of 61 patients was 1.00±0.52pmol/g tissue (mean±SD). Thus the upper limit (mean+2SD) of TS activity in normal gynecologic tissue was 2.00 pmol/g tissue. TS activity was generally higher in malignant tissue than in normal tissue, and particularly high activity was detected in cervical cancer. TS activity in endo‐metrial cancer was relatively low, but activity in poorly and moderately differentiated tumors was significantly elevated compared to well differentiated tumors. These findings suggest that cervical cancer is a highly proliferative tumor and that in endo‐metrial cancer, cell proliferation is more rapid in poorly differentiated tumors than in well differentiated ones.