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Effect of Menstruation on Serum CA125 Levels
Author(s) -
Kan YuenYee,
Yeh ShinHwa,
Ng HeungTat,
Lou ChingMee
Publication year - 1992
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1992.tb00329.x
Subject(s) - menstrual cycle , menstruation , medicine , follicular phase , endocrinology , serum concentration , mean value , chemistry , hormone , mathematics , statistics
CA125 levels were measured in the sera of 54 women with normal menstrual cycle and without infectious, benign and malignant gynecologic disorders. In 54 subjects studied, 13 (24%) had no significant variations in serum CA125 levels throughout the menstrual cycle. In contrast, there 41 (76%) had significant variations in serum CA125 with peak levels (51.8±6.5 U/m l , mean±SEM) during menstruation. The concentration reached a normal value (17.7±1.6 U/m l , mean±SEM) at proliferative phase, and remained low throughout the rest phases of the cycle. The mean peak level was significantly higher than that at proliferative phase (P<0.001), where as no significant difference in mean concentration was detected between sequential phases from proliferative phase to premenstrual phase (P>0.1). Among 41 with variable CA125 levels in the menstrual cycle, more than half of them, namely 39% of the total (21/54), had the levels of the upper limit or normal values.