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Thymidylate Synthase Inhibition as a Predictor of Tumor Sensitivity of Fluorinated Pyrimidines
Author(s) -
Suzuki Mitsuaki,
Sekiguchi Isao,
Tamada Taro
Publication year - 1990
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1990.tb00022.x
Subject(s) - thymidylate synthase , growth inhibition , chemistry , capsule , fluorouracil , cancer research , microbiology and biotechnology , cancer , medicine , biology , in vitro , biochemistry , botany
The thymidylate synthase (TS) content of tumor tissue was assayed and the levels of 5‐fluorouracil (5‐Fu) in serum and tumor tissue were determined in 21 patients with cervical cancer who were treated with UFT, a fluorinated pyrimidine. Subrenal capsule assay, a predictive tumor sensitivity test, was conducted concurrently on cervical tumor samples. TS inhibition and serum and tissue 5‐Fu levels widely varied between both samples. Investigation of the relationship between the tumor growth inhibition rate determined by subrenal capsule assay and the above parameters (TS inhibition, serum and tissue 5‐Fu levels) showed that TS inhibition and tumor growth inhibition were well correlated ( r =0.73). This suggests that a TS inhibition assay in tumor tissue can be a useful predictive test for tumor sensitivity of fluorinated pyrimidines.