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Induction of Endogenous Cytokines in Ascites of Patients with Ovarian Cancer by OK‐432, A Streptococcal Preparation
Author(s) -
Mori Hidehiro,
Itoh Naoki,
Yamada Yoshitaka,
Tamaya Teruhiko
Publication year - 1989
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1989.tb00190.x
Subject(s) - ascites , ascitic fluid , ovarian cancer , endogeny , medicine , tumor necrosis factor alpha , interferon , interleukin , immunology , cytokine , cancer research , cancer
To clarify the action mechanism of OK‐432, OK‐432 was intraperitoneally (i.p.) administered to 4 ovarian cancer patients with malignant ascites. In 2 of the 4 patients, 4 types of cytokines (tumor necrosis factor, interleukin 1 β, interleukin 2, and interferon γ) were induced in ascites after intraperitoneal injection of OK‐432 (i.p. OK‐432). In one of these patients, the ascitic supernatant after i.p. OK‐432 significantly inhibited colony formation of autologous ascitic tumor cells; the amount of ascites decreased markedly, and the ascitic cytology became negative. In the other 2 patients, only interferon γ was induced in ascites after i.p. OK‐432. In these 2, ascitic supernatant did not inhibit colony formation of autologous ascitic tumor cells. These results indicated that i.p. OK‐432 can induce various endogenous cytokines in malignant ascites and that these induced cytokines may contribute to the antitumor effect of i.p. OK‐432.