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Salt Loading Alters the Composition of Urinary Protein in Pregnant Spontaneously Hypertensive Rats
Author(s) -
Kurokawa Tatsuro,
Shimokawa Hiroshi,
Matsukuma Keita,
Ishida Kiyoshi,
Miyamoto Shingo,
Nakano Hitoo
Publication year - 1988
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1988.tb00139.x
Subject(s) - urinary system , gestation , endocrinology , medicine , pregnancy , histology , salt (chemistry) , low protein diet , tap water , composition (language) , chemistry , biology , engineering , linguistics , philosophy , environmental engineering , genetics
The influence of salt loading on the composition of urinary protein in pregnant spontaneously hypertensive rats (SHR) was examined. The amount of daily urinary protein increased significantly in salt loaded pregnant SHR, compared to that in pregnant SHR given tap water. The composition of urinary protein changed from a low molecular weight protein dominant pattern to a 71 × 10 3 molecular weight protein dominant pattern at 13 days of gestation in salt loaded SHR. In SHR given only tap water, the composition of urinary protein remained unaltered during pregnancy. Histology of the kidneys from both groups showed a normal architecture. The results suggest that excessive salt intake during pregnancy may affect the glomerular permeability to large molecular weight protein.