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Comparison of Pharyngeal Aspiration and Amniotic Fluid Surfactant Phospholipids for Prediction of RDS
Author(s) -
Dhall Kamala,
Gupta Neelam,
Majumdar Siddhartha,
Bhakoo Onkar N.
Publication year - 1988
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1988.tb00116.x
Subject(s) - amniotic fluid , phosphatidylglycerol , lecithin , pulmonary surfactant , respiratory distress , amniocentesis , sphingomyelin , medicine , phospholipid , chemistry , chromatography , phosphatidylcholine , fetus , anesthesia , pregnancy , biology , biochemistry , membrane , cholesterol , prenatal diagnosis , genetics
Pulmonary surfactant phospholipids in nasopharyngeal aspirate have been compared with the corresponding parameters in amniotic fluid (AF) in 108 cases for prediction of respiratory distress syndrome (RDS) in the newborn. The concentration of phospholipids [lecithin sphingomyelin ratio (L/S) and phosphatidylglycerol (PG)] rises with the rising periods of gestation in both the fluids. When 2 groups of samples were compared, the values of phospholipids were higher in pharyngeal aspirate (PA) than in amniotic fluid (AF). These differences were statistically significant in case of PG but not in case of L/S ratio. Time interval between AF and PA collection, neonatal weight and Apgar score did not influence the concentration of phospholipids in AF and PA. The mature value, i.e. positive test could predict freedom from RDS in 99 to 100% of cases with PG and L/S in both the fluids respectively whereas predictability with negative test though less, was higher with phospholipids in AF than in PA.