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Maturity and in vitro Fertilization of Superovulated Human Oocytes in Relation to Various Hormone Levels in Follicular Fluids
Author(s) -
Chang Yoon Seok,
Lee Jin Yong,
Moon Shin Yong,
Kim Jung Gu,
Yoon Bo Hyun
Publication year - 1988
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1988.tb00102.x
Subject(s) - follicular phase , medicine , follicular fluid , endocrinology , androstenedione , ovulation , human fertilization , ovulation induction , oocyte , in vitro fertilisation , gonadotropin , prolactin , embryo transfer , testosterone (patch) , follicle stimulating hormone , hormone , menotropins , follicle , biology , pregnancy , androgen , embryo , luteinizing hormone , genetics , microbiology and biotechnology , agronomy
Follicular fluid (FF) prolactin (PRL), follicle stimulating hormone (FSH), estradiol (E 2 ), progesterone (P), androstenedione (ADD) and testosterone (T) levels were compared in 3 groups of spontaneously ovulatory women undergoing ovulation induction with clomiphene citrate (CC) alone or with human menopausal gonadotropin (hMG) (15 patients), hMG (8 patients), or pure FSH/hMG (9 patients) for the purpose of in vitro fertilization. FF hormone levels measured did not differ significantly according to the maturity of the oocyte. FF FSH and T levels for all three groups were similar, but the PRL concentrations were significantly lower in the CC‐treated group than in the other groups. E 2 was highest in FF from CC‐treated group compared to the hMG‐treated or FSH‐treated group. FF P values were highest in CC‐treated group. And hMG‐stimulated follicles contained significantly lower ADD than did the other groups. However, in all treatment groups, FF levels of various hormone measured did not show any close relationship with fertilization and the success of pregnancy after embryo transfer. In conclusion, follicular development and steroidogenesis differs markedly depending on the agent used for follicular stimulation. But these alterations may not impair oocyte development, successful fertilization and implantation.