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FSH, LH, PRL and E2 Levels in Follicular Fluid and Serum of Patients Undergoing Follicle Stimulation with Different Protocols for IVF
Author(s) -
Shin MinTsir,
Chu TangYuan,
Hsu ChihHsueh,
Yu MuHsien,
Chang JiaShyuhn,
Sun David,
Lao ZenHwa,
Wu KwoTsang,
Lee ChiaKoon,
Yang ChiLiu,
Hsu ChienTien
Publication year - 1988
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1988.tb00099.x
Subject(s) - follicular fluid , follicular phase , medicine , ovulation , oocyte , endocrinology , radioimmunoassay , follicle stimulating hormone , luteinizing hormone , hormone , ovulation induction , gonadotropin , menotropins , follicle , hmg coa reductase , stimulation , andrology , chemistry , biology , embryo , biochemistry , enzyme , reductase , microbiology and biotechnology
Concentrations of FSH, LH, PRL and E2 in plasma and in follicular fluid were studied by radioimmunoassay in 74 cycles induced for IVF. Three different protocols were used for induction of super‐ovulation: Clomiphene/HCG, clomiphene/HMG/HCG and HMG/HCG. The results showed that the 2 HMG‐treated groups showed significantly higher serum E2 and PRL, and lower LH levels than the clomiphene‐treated group. Similarly, the HMG‐treated protocols also induced more FSH, PRL and E2 in follicular fluid than the clomiphene‐treated protocol, while LH in the follicular fluid in 3 protocols were very close. On the basis of the hormone profiles in serum and follicular fluid noted in this study, we concluded that the HMG‐treated protocol produced a more favorable systemic and local environment for oocyte maturation. PRL levels in serum and follicular fluid, like E2, seemed to be an indicator of oocyte maturation. The LH‐surge inhibition effect of HMG was also confirmed in this study.