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The Effect of a Serine Proteinase Inhibitor on DIC in Septic Abortion
Author(s) -
Takeda Satoru,
Kumc Masao,
Takechi Kimihiro,
Kasamatsu Takahiro,
Yoshida Koji,
Kinoshita Katsuyuki,
Mizuno Masahiko,
Sakamoto Shoichi
Publication year - 1987
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1987.tb00287.x
Subject(s) - septic abortion , proteinase inhibitor , septic shock , medicine , coagulopathy , abortion , heparin , disseminated intravascular coagulation , serine proteinase inhibitors , intensive care medicine , pregnancy , surgery , sepsis , serine protease , chemistry , biochemistry , enzyme , genetics , protease , biology
A 21‐year‐old woman developed septic shock complicated by acute renal insufficiency after D & C to terminate early pregnancy. Although immediate and aggressive treatment improved the profound cardiovascular collapse, DIC became manifest. Gabexate mesilate, a serine proteinase inhibitor, was substituted for heparin and was beneficial in controlling the coagulopathy. In this case study, the efficacy of gabexate mesilate on DIC as well as the management and treatment of septic abortion are discussed.