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High Risk Factors for Cancer of the Endometrium among Japanese Women
Author(s) -
Noda Kiichiro,
Yanagawa Hiroshi,
Kurihara Souju,
Sugimoto Osamu,
Takamizawa Hiroyoshi,
Tenjin Yoshio,
Okudaira Yoshio,
Suzuki Tadao,
Morizuka Takejiro,
Moriwaki Shosuke,
Matsuzawa Masumi,
Ichinoe Kihyoe,
Kasamatsu Tatsuhiro,
Yajima Akira,
Ishida Reisai,
Hando Tamotsu,
Nishiya Iwao,
Kurano Akihiko,
Ichikawa Kimiho,
Kuramoto Hiroyuki,
Inoue Yoshiki
Publication year - 1987
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1987.tb00279.x
Subject(s) - endometrial cancer , medicine , cancer , gynecology , endometrium , obstetrics , family history , pregnancy , incidence (geometry) , physics , biology , optics , genetics
Abstract From a national survey on patients treated for cancer of the endometrium between 1980 and 1981 in Japan, it was found that the incidence of such cancers was 4.2 patients per 100,000 women (based upon approximately 2,500 cases). The mortality rate for endometrial cancer was 0.5 per 100,000 (based upon approximately 300 deaths). Interviews were held with 232 patients with cancer of the endometrium and with women from 2 control groups. The women in the control groups were gynecological patients of approximately the same age as the endometrial cancer patients, thus allowing for analysis of the high risk factors in this form of cancer. The factors which showed significantly high relative risk of cancer of the endometrium were: (I) irregularity of the menstrual cycle after the age of 30, (II) postmenopausal state, (III) unmarried status, (IV) advanced age at first marriage, (V) no history of pregnancy, (VI) a small number of pregnancies or births, (VII) no experience of contraception, (VIII) sparse lactation, and (IX) history of hormone therapy. Other factors which tended to increase risk, but did not reach statistical significance were: (I) hypertension, (II) history of diabetes or non‐endotnetrial tumors, and (III) age of parents at the time of birth over 35. Factors which were virtually indistinguishable from those of the controls included: (I) body weight, (II) irregularity of the menstrual cycle prior to the age of 20, (III) dysmenorrhea, (IV) tobacco usage, (V) alcohol usage, and (VI) dietary habits (consumption of meat, eggs and fruit).