Premium
Plasma Prolactin and Dehydroepiandrosterone Sulfate Levels in Polycystic Ovarian Disease
Author(s) -
Lee Jin Yong,
Yoon Byung Koo,
Moon Shin Yong,
Kim Jung Gu,
Chang Yoon Seok
Publication year - 1987
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1987.tb00253.x
Subject(s) - dehydroepiandrosterone sulfate , polycystic ovarian disease , medicine , endocrinology , dehydroepiandrosterone , androgen , prolactin , adrenal cortex , polycystic ovary , hormone , obesity , insulin resistance
This study was undertaken to evaluate the prevalence rate of hyperprolactinemia (HPRL) in polycystic ovarian disease (PCOD), and to ascertain the effect of HPRL on androgen production of the adrenal cortex as well as the adrenal participation in PCOD by measuring plasma dehydroepiandrosterone sulfate (DHEAS). This study included 43 patients with PCOD and 20 normal control women. HPRL was found in 7 (16.3%) of 43 patients with PCOD. The mean plasma DHEAS level was significantly higher in patients with hyperprolactinemic PCOD than in patients with nor‐moprolactinemic PCOD. A significant positive correlation was found between plasma prolactin (PRL) and DHEAS value in the hyperprolactinemic group. [The mean plasma DHEAS concentration was significantly elevated in patients with PCOD than in normal controls. Hirsute PCOD patients had a significantly higher mean plasma level of DHEAS than non‐hirsute group. These data show a distinct profile of androgen levels in patient with PCOD and suggested that higher levels of PRL in PCOD is significantly associated with elevated DHEAS.