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Hydatidiform Mole: Patient Profile and the Impact of Prophylactic Chemotherapy at the Philippine General Hospital, 1975–1983
Author(s) -
IsidroGutierrez Rosario F.,
PaloGarcoa Fe,
BlancoCapito Lourdes R.
Publication year - 1987
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1987.tb00246.x
Subject(s) - methotrexate , chemotherapy , medicine , mole , choriocarcinoma , general hospital , disease , gynecology , surgery , pediatrics
The clinical profile of patients with hydatidiform mole admitted to the Philippine General Hospital is presented. In this study prophylactic chemotherapy for hydatidiform mole had its advantages and its risks. It reduced the development of post‐molar non‐metastatic trophoblastic disease (NMTD) and metastatic trophoblastic disease (MTD). However, it also showed that toxicity to methotrexate could be severe even with the first course. At the Philippine General Hospital the authors found it advisable to limit its use to patients who are at greater risk of developing trophoblastic sequelae.