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Serum Levels of Norethisterone, Estradiol and Progesterone after Administration of Norethisterone Oenanthate at Different Sites: A Cross‐Over Study
Author(s) -
Virutamasen Pramuan,
Dhanapas Siriporn,
Leepipatpaiboon Samai
Publication year - 1987
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1987.tb00008.x
Subject(s) - norethisterone , medicine , endocrinology , radioimmunoassay , norethisterone acetate , hormone , steroid , population , research methodology , environmental health
Twenty healthy female volunteers were enrolled of this study. The subjects were randomly divided into 10 for each group. One group received a single injection of norethisterone oenanthate (NET‐EN) via gluteal muscle, the rest received NET‐EN via deltoid muscle. The study had a cross‐over design and after the first injection period of 8 weeks, there was a steroid‐free period of 8 weeks. Blood samples were collected weekly. The serum concentration of norethisterone, estradiol and progesterone were measured by radioimmunoassay. It was found that the elimination rate constant, Tl/2 and area under the curve for the gluteal and deltoid group were not significantly different. The peak levels of NET in the serum was somewhat high in the deltoid injection group. The ovarian suppression with NET‐EN in some women may last only 60 days or less.