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Maternal Serum Diamine Oxidase Activity in the Third Trimester
Author(s) -
Legge M.,
Hammond E. M.,
Ncwsomc B. J.,
Duff G. B.,
Aickin D. R.
Publication year - 1986
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1986.tb00224.x
Subject(s) - diamine oxidase , amine oxidase (copper containing) , pregnancy , medicine , diabetes mellitus , fetus , third trimester , obstetrics , endocrinology , chemistry , enzyme , biochemistry , biology , genetics
Serum diamine oxidase activity was determined serially in 192 women in the third trimester of pregnancy. Maternal and fetal complications were absent in 74 of these women but 21 delivered light for dates infants, 18 delivered heavy for dates infants, 58 developed mild hypertension, 14 developed moderate hypertension and seven developed severe hypertension of pregnancy. In addition there were six women whose pregnancies were complicated by diabetes mellitus. Diamine oxidase activity was significantly lower among those pregnancies with light for dates infants and those pregnancies complicated by maternal hypertension. The pregnancies complicated by diabetes mellitus also demonstrated low diamine oxidase activity but the numbers were too few to assess statistically. Pregnancies with heavy for dates infants did not show any significant difference in diamine oxidase activity from normal pregnancies. The low diamine oxidase activity found in some pregnancy complications may indicate a failure of adequate substrate being available to initiate polyamine biosynthesis.