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In vitro Fertilization Applied for Tubal and Non‐Tubal Causes of Infertility
Author(s) -
Yovich John L.,
Yovich Jeanne M.,
Tuvik Ann I,
Junk Stephen,
Bootsma Barbara,
PhD Phillip L. Matson
Publication year - 1986
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1986.tb00222.x
Subject(s) - semen , gynecology , infertility , in vitro fertilisation , artificial insemination , endometriosis , pregnancy , pregnancy rate , sperm washing , medicine , obstetrics , insemination , andrology , human fertilization , biology , sperm , genetics , anatomy
A combined service and research program of IVF‐ET was established at PIVET Laboratory, Perth, Western Australia in 1981. By May 1985, 592 couples have had a mean of 1.66 treatment cycles with a total of 140 pregnancies achieved (23.7% per couple). The earliest cases were treated for occlusive tubal disease, but increasingly, a wide range of infertility disorders have been managed by IVF‐ET. The pregnancy rate achieved for tubal disease was 23.3%. Rates are significantly lower in women with endometriosis (9.1%; p<0.01) and significantly higher where the woman has no recognizable factor (including those treated for failed artificial insemination by donor semen) and those with circulating antispermatozoal antibodies (up to 47.6%; p<0.001). With regard to male factors, applying the treatment methods described, pregnancy rates did not vary between groups (mean 23.7%) although donor semen was used where an insufficient number of motile spermatozoa was obtained from husband's semen.