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Small‐for‐Gestational‐Age (SGA) Neonates: A Study of Blood Coagulation and Fibrinolysis
Author(s) -
Fuse Yoji
Publication year - 1986
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1986.tb00193.x
Subject(s) - fibrinolysis , medicine , small for gestational age , gestational age , obstetrics , coagulation , birth weight , pregnancy , biology , genetics
The author examined 68 subjects with normal pregnancy and delivery for blood coagulation and fibrinolysis to determine the cause of birth of small‐for‐gestational‐age (SGA) neonates. In the umbilical blood, the SGA group showed significant decreases in platelet count, plasminogen and alpha 2 ‐plasmin inhibitor (p < 0.05), as compared with the appropriate‐for‐gestational‐age (AGA) and large‐for‐gestational‐age (LGA) group. In the maternal blood in the third trimester, the SGA‐neonate‐delivery group showed hypercoagulation, inhibition of fibrinolysis and platelet hyperfunction, as compared with the AGA‐ and LGA‐ neonate‐delivery groups. Particularly, prothrombin time significantly decreased (p < 0.002). There was a correlation between prothrombin time of the maternal blood and neonatal birth weight (r = 0.38446, p < 0.01). The above results suggested that these changes in blood coagulation and fibrinolysis had an influence on the decrease in the utero‐placental blood flow, related to the birth of SGA neonates. It was also inferred that prothrombin time of the maternal blood in the third trimester can become a parameter for predicting the birth of a SGA neonate.