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Determinants of Risk for Developing Invasive Mole and Choriocarcinoma Following Hydatidiform Mole
Author(s) -
Hara Takako,
Kaseki Shigeaki,
Tomoda Yutaka,
Nishikawa Yoshiki,
Ishizuka Takao,
Ishizuka Naotaka
Publication year - 1986
Publication title -
asia‐oceania journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 50
eISSN - 1447-0756
pISSN - 0389-2328
DOI - 10.1111/j.1447-0756.1986.tb00187.x
Subject(s) - choriocarcinoma , mole , molar pregnancy , molar , gynecology , medicine , partial hydatidiform mole , obstetrics , gestational trophoblastic disease , pregnancy , biology , gestation , fetus , placenta , genetics , dentistry
In Aichi prefecture, Japan, 4, 547 hydatidiform moles were registered from 1962 to 1977. Among these hydatidiform moles, 94 choriocarcinomas, 377 invasive moles and 4 undetermined cases occurred until April 1985. In this paper, the high risk factors for post‐molar trophoblastic disease were studied. The results were:1 The frequency of mole was one per 349.7 deliveries in Aichi, Japan. 2 89.8% of invasive moles were diagnosed by the end of the third month after molar evacuation, whereas 42% of choriocarcinomas were found by the end of the 1st year. The necessity of at least 4 years of supervision and follow up was emphasized. 3 Increased age (>40), the patient's blood type (AB) and the husband's blood type (B) were high risk factors for post‐molar trophoblastic disease, whereas multi‐parity and Rh‐d factor were suggested to lower the risk.